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A person with von Willebrand disease (VWD) or a platelet disorder will have trouble making a platelet plug. Some people with von Willebrand Disease (VWD) also have trouble making a fibrin clot because they do not have enough factor VIII. Without a platelet plug, blood will continue to leak from the blood vessel. In time, the body can make a fibrin clot to stop the bleeding but it will not be as strong as a clot that had a good platelet plug.

If a person’s platelets have trouble sticking to the wall of an injured blood vessel, he or she has an adhesion disorder. If the platelets do not stick well to each other, it is an aggregation disorder. If the platelets do not release the chemicals that signal other platelets to join in making the plug, it is a secretion disorder.

This was sourced from The VWD & Platelet Disorder Handbook, 2007 (page 9)

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